PATHOMORPHOLOGICAL CHANGES IN THE STRUCTURAL COMPONENTS OF PANCREATIC TISSUE IN THE OFFSPRING OF DIABETIC MOTHER RATS (LITERATURE REVIEW)
Keywords:
Diabetes mellitus, morphology, morphometry, stomach, postnatal ontogenesis, intact rats.Abstract
In recent years, diabetes mellitus has become a widespread endocrine disorder and a significant medical and social problem for many countries. This is often associated with the high frequency of various complications of the disease (blindness, small intestine insufficiency, myocardial infarction, gastrointestinal system disorders, gangrene of the limbs, etc.). These complications, in turn, lead to loss of working capacity and disability in patients. Although damage to various organs in diabetes mellitus has been extensively studied, unfortunately, the morphofunctional condition of organs, particularly the vascular and tissue structures of the stomach, has not yet been sufficiently explored in depth. To date, the morphofunctional features and pathogenesis mechanisms of organ damage in diabetes mellitus, especially the ante- and postnatal morphogenesis of internal organs and the pathomorphological mechanisms of damage in offspring born to diabetic mothers, have not been adequately investigated. However, an in-depth study of this disease opens up opportunities to influence the outcome of complications, and to improve the quality and effectiveness of treatment.Thus, the search for solutions to these issues highlights the relevance and significance of problems in this field.
References
Belousov Yu. A., Trefilov G. V. Morphological changes in some internal organs of white rats with alloxan diabetes // Endocrine mechanisms of regulation of the body's adaptation to muscular activity. – P. 233.
Boychuk T. N., Olenovich O. A., Gritsyuk M. I., Gozhenko A. I. Functional state abnormalities of the kidneys in the early period of experimental diabetes mellitus // International Endocrinology Journal. – 2017. – Vol. 13, No. 6. – Pp. 463-467.
Bolin E. H., Spray B. J., Mourani P. M., Porter C., Collins R. T. 2nd. Mortality among infants of diabetic mothers with hypertrophic cardiomyopathy // Journal of Maternal-Fetal & Neonatal Medicine. – 2022 Dec; 35(25): 9893-9899.
Kharitonova L. A. et al. Health status of children born to mothers with diabetes mellitus // Russian Journal of Perinatology and Pediatrics. – 2018. – Vol. 63. – No. 3. – Pp. 26-31.
Koshelskaia O. A. Features of intrarenal blood flow Doppler indicators in type 2 diabetes mellitus and its association with arterial hypertension: Scientific publication.
Kharitonova L. A., Papysheva O. V., Bogomaz L. V., Bogomaz D. S. Monitoring of children born to mothers with various carbohydrate metabolism disorders // St. Petersburg Gastroenterology. – 2019. – No. 2. – Pp. 45-46.
Kharitonova L. A., Papysheva O. V., Mayatskaya T. A. Functional activity and formation features of intestinal microbiota in children born to mothers with gestational diabetes mellitus // Higher School: Scientific Research. Materials of the Interuniversity International Congress. – Moscow, 2021. – Pp. 92-103.
Lysenko S. N. et al. The fetal pancreas in normal and diabetes-complicated pregnancies // Doctor. – 2013. – No. 8. – Pp. 62-64.
Mayatskaya T. A., Kharitonova L. A., Papysheva O. V., Zatevalov A. M. Formation of intestinal microbiocenosis in children born to mothers with gestational diabetes mellitus // Experimental and Clinical Gastroenterology. – 2021. – No. 1 (185). – Pp. 96-105
Oksuzyan A. V. Sialoglycoprotein metabolism in the small intestine tissues of rats with different stress resistance under dalargin administration in experimental diabetes conditions // Modern Problems of Science and Education. – 2019. – No. 1. – P. 24.
Palchikova N. A., Kuznetsova N. V., Kuzminova O. I., Selyatitskaya V. G. Hormonal and biochemical characteristics of alloxan and streptozotocin models of experimental diabetes // Siberian Scientific Medical Journal. – 2013. – Vol. 33, No. 6. – Pp. 18-24.
Yuldashev A. Yu. et al. Morphological features of fundic stomach mucosa formation in rats during postnatal ontogenesis // World of Medicine and Biology. – 2014. – Vol. 10. – No. 4-2 (47). – Pp. 214-219.
Yuldasheva S. Z., Abdiramonova S. A. Development of digestive-absorptive and immune systems in the small intestine mucosa during early postnatal ontogenesis // Innovative Processes in the Scientific Environment: International Scientific and Practical Conference Proceedings. – Perm: Aeterna LLC, 2017. – Pp. 220-226.
Zverev Ya. F., Rykunova A. Ya. Nephroprotective effects of new hypoglycemic drugs: SGLT2 inhibitors: review // Nephrology: scientific and practical peer-reviewed journal. – St. Petersburg: “Levsha” Publishing House. – 2021. – Vol. 25, No. 4. – Pp. 11-22.
Zatolokina M. A. Morphological features of the small intestine mucosa in embryos and newborn rats // Regional Bulletin. – 2020. – No. 12. – Pp. 11-12.