MORPHOLOGICAL CHANGES IN THE LONG TUBULAR BONES OF RATS IN EXPERIMENTAL OSTEOPOROSIS

Authors

  • Mardon I. Ollaberganov
  • Rashid Y. Ruzibaev
  • Guzal I. Madaminova

Keywords:

experimental osteoporosis, gastric resection, bone tissue, morphometry

Abstract

After gastric resection, most patients experience serious digestive disorders, a decrease in body weight [1] and the appearance of severe clinical manifestations of a number of diseases [10]. The gastrointestinal tract (GIT), as one of the subsystems of bone mineral metabolism, takes an active part in maintaining the age-related bone mass constant [4]. In diseases of the gastrointestinal tract, the absorption of minerals and vitamins (including Ca and vitamin D) is impaired. This leads to a decrease in the calcium content in bone tissue, a decrease in bone mineral density (BMD) – osteoporosis [6]. In our study, the experimental condition of osteoporosis was created by removing a certain part of the stomach by simulating the method of gastric resection by the Billroth-II method. Purpose of the study: creation of an experimental state of osteoporosis by gastric resection in experimental rats by the Billroth-II method. Study of the morphometric state of bone tissue in long tubular bones and the stomach wall. Material and methods. 27 white male rats weighing 170-200 g from the Vistar line were selected. Of these, 12 rats were divided as a control group and 15 as an experimental group. The rats of the experimental group underwent gastric resection using the Billroth-II method, and three months later morphometric changes in the long tubular bones and the stomach wall were studied. Conclusion: removal of a certain part of the stomach in experimental animals in the form of resection according to Billrot-II led to a significant morphological change in its wall, osteomorphometric parameters and architectonics of the long tubular bone.

Author Biographies

Mardon I. Ollaberganov

Assistant of the Department of Nephrology, Hemodialysis, Traumatology and Orthopedics, Urgench branch of Tashkent Medical Academy, Uzbekistan

E-mail: mardon_2288@list.ru

Rashid Y. Ruzibaev

DSc., Head of the Department of Nephrology, Hemodialysis, Traumatology and Orthopedics. Urgench branch of Tashkent Medical Academy, Uzbekistan

E-mail: rach_ter@rambler.ru

Guzal I. Madaminova

Senior Lecturer at the Department of Clinical Anatomy and Histology. Urgench branch of Tashkent Medical Academy, Uzbekistan

E-mail: guzal.madminova@bk.ru

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Published

2022-04-04

How to Cite

Mardon I. Ollaberganov, Rashid Y. Ruzibaev, & Guzal I. Madaminova. (2022). MORPHOLOGICAL CHANGES IN THE LONG TUBULAR BONES OF RATS IN EXPERIMENTAL OSTEOPOROSIS. Central Asian Journal of Medicine, (1), 28-32. Retrieved from https://mail.journals.tma.uz/index.php/cajm/article/view/480

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