FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS

Authors

  • Ulugbek S. Khasanov
  • Ulugbek N. Vokhidov
  • Jamolbek A. Djuraev

Keywords:

paranasal sinuses, polyp, allele, genotyping

Abstract

Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C/C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. In addition, these data emphasize the prognostic significance of the C/C genotype of the rs1800896 polymorphism of the IL-12B gene in the development of CPMS. In carriers of this genotype, the relative risk of developing CPMS increases by more than 3 times, compared with carriers of other genotypic variants of the rs3212227 polymorphism of the IL12B gene.

Author Biographies

Ulugbek S. Khasanov

MD, Professor, Head of the department of Otolaryngology and stomatology,
Tashkent medical academy, Uzbekistan

E-mail: ukhasanov@yahoo.com

Ulugbek N. Vokhidov

MD, Docent of the department of Otolaryngology,
Tashkent State Dental Institute, Uzbekistan

E-mail: dr_ulugbek@list.ru

Jamolbek A. Djuraev

MD, Docent of the department of Otolaryngology and stomatology,
Tashkent medical academy, Uzbekistan

E-mail: drdjuraev@mail.ru

Downloads

Published

2023-06-02

How to Cite

Ulugbek S. Khasanov, Ulugbek N. Vokhidov, & Jamolbek A. Djuraev. (2023). FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS. Central Asian Journal of Medicine, (3), 5-15. Retrieved from https://mail.journals.tma.uz/index.php/cajm/article/view/497

Issue

Section

Articles