ULINASTATIN IN THE CONSERVATIVE THERAPY OF CHRONIC PANCREATITIS

Authors

  • Mirvosit M. Karimov
  • Pulat S. Zufarov
  • Go’zal N. Sobirova
  • Nargiza I. Pulatova
  • Shahlo S. Aripdjanova

Keywords:

chronic pancreatitis, etiology, treatment, clinical, adverse reaction

Abstract

The article presents the results of the anti-inflammatory efficacy of the new generation protease inhibitor ulinastatin in the treatment of exacerbation of chronic pancreatitis of moderate severity. It is shown that exacerbation of chronic pancreatitis of alimentary, alcoholic and biliary etiology was expressed by abdominal pain and dyspeptic symptoms. An increase in the level of serum aminotransferases, bilirubin and alpha amylase was noted, which was accompanied by a significant increase in the activity of pro-inflammatory cytokines. The use of ulinastatin in the complex of pharmacotherapy of chronic pancreatitis contributed to the effective relief of exacerbation of pancreatitis, which was due to the anticytokine effect of the drug.

Author Biographies

Mirvosit M. Karimov

DSc, Professor, Head of the Department of Gastroenterology
of the Republican Specialized Scientific and Practical Medical Center for
Therapy and Medical Rehabilitation, Uzbekistan

Pulat S. Zufarov

DSc, Professor of the Department of Clinical Pharmacology
of the Tashkent Medical Academy, Uzbekistan

E-mail: pulatzufarov@gmail.com

Go’zal N. Sobirova

DSc, Associate Professor of the Department of Rehabilitation
and Traditional Medicine of the Tashkent Medical Academy, Uzbekistan

Nargiza I. Pulatova

DSc, Assistant of the Department of Clinical Pharmacology
of the Tashkent Medical Academy, Uzbekistan

Shahlo S. Aripdjanova

PhD, Assistant of the Department of Clinical Pharmacology
of the Tashkent Medical Academy, Uzbekistan

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Published

2022-10-03

How to Cite

Mirvosit M. Karimov, Pulat S. Zufarov, Go’zal N. Sobirova, Nargiza I. Pulatova, & Shahlo S. Aripdjanova. (2022). ULINASTATIN IN THE CONSERVATIVE THERAPY OF CHRONIC PANCREATITIS. Central Asian Journal of Medicine, (3), 54-61. Retrieved from https://mail.journals.tma.uz/index.php/cajm/article/view/502

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