THE POSSIBLE ROLE OF CHRONIC CONSUMPTION OF SODIUM CYCLAMAT IN THE DEVELOPMENT OF HYPERGLYCEMIA AND INSULIN RESISTANCE
Keywords:
insulin resistance, sodium cyclamate, HOMA-IR, IRI, glycated haemoglobin, obesity, insulin, HDL, LDL, cholesterole, triglycerides.Abstract
In the experiment, 10 mg/kg of sodium cyclamate which is widely used in the food industry, was dissolved in distilled water was administered to the rats during the 60 days and carbohydrate, protein, fat and microelement’s metabolism were analyzed. The possible role of sodium cyclamate in the origin of insulin resistance was evaluated by chronic administration of a sodium cyclamate. The results show that it can lead to progressive increase in blood glucose levels, hyperinsulinemia and insulin resistance if consumed chronically. In addition, it was found that cyclamate affects the metabolism of proteins, fats and microelements, causing an increase in the indicators of uric acid and creatinine, lipid spectrum, and a decrease in the amount of microelements in the blood. Despite the fact that cyclamate is 30 times sweeter than sugar and economically cheaper, its permitted dose can have a harmful effect. The results suggest that the use of cyclamate should be limited or used in combination with agents that reduce its negative effects.
