HEPATOPROTECTIVE PROPERTIES OF NANOSULFATE CHITOSAN ON THE MODEL OF ACUTE TETRACHLORMETHANE HEPATITIS

Authors

  • Zulfiya I. Galieva
  • Firuza Kh. Inoyatova
  • Vazira Rakhmanova
  • Rakiya Yu. Milusheva
  • Sayora Sh. Rashidova

Keywords:

acute toxic liver injury, hepatoprotectors, carsil, low molecular weight chitosan, nanosulfate chitosan, cytolysis, cholestasis, mesenchymal inflammation syndromes, lipid peroxidation, apoptosis, histology

Abstract

The effects of low molecular weight chitosan (LMWC) and nanosulfate chitosan (NSC) were studied in comparison with the classical hepatoprotector carsil on the model of tetrachlormethane acute toxic liver injury (ATLI). The optimal hepatoprotective doses of LMWC 25 microg and NSC 10 mg/kg were established for oral administration for 12 days after reproducing the ATLI model. The drugs in these concentrations restored the detoxifying function of hepatocytes, reduced the severity of cytolysis, cholestasis, mesenchymal inflammation, hepatocellular insufficiency syndromes, activated antioxidant activity and reduced high values of lipid peroxidation and apoptosis.

Author Biographies

Zulfiya I. Galieva

basic doctoral student of biological chemistry of
Tashkent Medical Academy, Tashkent, Uzbekistan

Firuza Kh. Inoyatova

DSc, B.D., Associate Professor, Head of the Department of biological chemistry of Tashkent Medical Academy, Tashkent, Uzbekistan

Vazira Rakhmanova

PhD, Associate Professor, Head of the Institute of Polymer Chemistry and Physics Academy of Science of the Republic Uzbekistan, Tashkent, Uzbekistan

Rakiya Yu. Milusheva

PhD, Associate Professor, Head of the Institute of Polymer Chemistry and Physics Academy of Science of the Republic Uzbekistan, Tashkent, Uzbekistan

Sayora Sh. Rashidova

DSc, Ch.D., Associate Professor, Head of the Institute of Polymer Chemistry and Physics Academy of Science of the Republic Uzbekistan

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Published

2024-07-04

How to Cite

Zulfiya I. Galieva, Firuza Kh. Inoyatova, Vazira Rakhmanova, Rakiya Yu. Milusheva, & Sayora Sh. Rashidova. (2024). HEPATOPROTECTIVE PROPERTIES OF NANOSULFATE CHITOSAN ON THE MODEL OF ACUTE TETRACHLORMETHANE HEPATITIS. Central Asian Journal of Medicine, (2), 49-58. Retrieved from https://mail.journals.tma.uz/index.php/cajm/article/view/830

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