IMMUNOHISTOCHEMICAL EVALUATION OF PULMONARY MICROVASCULAR ENDOTHELIUM IN ALLOXAN-INDUCED DIABETES

Authors

  • Dildova R. Sobirova

Keywords:

experimental diabetes, immunohistochemistry, endothelial cells, VEGFA-1, ICAM1, neovascularization, pathological vascularization, diabetic angiopathy, inflammation, vascular pathology.

Abstract

This study focuses on the immunohistochemical changes in endothelial cells of lung vessels in experimental diabetes. The increased expression of VEGFA-1 and ICAM1 markers indicates endothelial cell damage, new vessel formation, and activation of the neoangiogenesis process. These markers play a crucial role in assessing damage and inflammation processes, as well as understanding pathological vascularization in diabetes. The findings demonstrate the role of VEGFA-1 and ICAM1 markers in the development of diabetic angiopathy and vascular pathology.

Author Biography

Dildova R. Sobirova

Doctor of Philosophy, Associate professor of the Department of Histology and medical biology at Tashkent Medical Academy, Tashkent, Uzbekistan

E-mail: dildorasobirovatma2020@gmail.com

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Published

2025-02-05

How to Cite

Dildova R. Sobirova. (2025). IMMUNOHISTOCHEMICAL EVALUATION OF PULMONARY MICROVASCULAR ENDOTHELIUM IN ALLOXAN-INDUCED DIABETES. Central Asian Journal of Medicine, (1), 61-68. Retrieved from https://mail.journals.tma.uz/index.php/cajm/article/view/993

Issue

No. 1 (2025): CAJM

Section

Articles