A PATHOGENETICALLY JUSTIFIED APPROACH TO COMPLEX THERAPY OF BASIC NEUROLOGICAL SYNDROMES IN HIV PATIENTS

Abstract

Objective: To develop a pathogenetically substantiated approach to the complex therapy of the main neurological and
methods: The study was based on data from 103 patients with HIV infection (54.4% of women and 45.6% of men) who are
in the dispensary register, aged 20 to 45 years. Neuropsychological studies of patients with HIV infection were carried out
using special tests: Wechsler Memory Scale Memory Scale, (WMS), 7 subtests, Schulte table, “Incomplete Outlines of Objects”
(A.R. Luria). The efficacy of citicoline (1000 mg / day) when added to basic HIV treatment was studied in 53 patients. The
comparison group consisted of 50 HIV patients who did not receive neuroprotective therapy. The efficacy of treatment was
assessed according to the CGI clinical scale (the scale of the overall clinical impression - Clinical Global Impression). Results:
At early preclinical stages of HIV, memory disorders were noted in 64% of those examined and mainly affected short-term
auditory and visual types of memory, attention disorders were expressed in the form of exhaustion (51.2%). At the stage of HIV
progression to the development of opportunistic infections, memory disorders were noted in 78% of patients and affected logical,
visual and associative memory types. Violations of attention were expressed in the decrease in work efficiency (in 22.6%), the
degree of workability (in 43.3%) and exhaustion (in 66%).Conclusions: the identification of early symptoms of manifestation
of neurological disorders in HIV and the timely appointment of complex therapy, including antiviral drugs, vascular drugs and
neuroprotective therapy can stabilize the condition of patients, reduce the severity and progression of neurological symptoms.
This study demonstrated the efficacy of citicoline (ceraxone) in the treatment of neurological disorders in patients with HIV.