SIGNIFICANCE OF MARKERS IN INFLAMMATORY AND CONNECTIVE TISSUE AT TEMPOROMANDIBULAR JOINT DISEASESIN CHILDREN

Abstract

To study features of some connective tissue markers in development of TMJ pathology at children. Materials
and methods: Research has been based on medical examination results of 65 children in aged 6 to 15 years with TMJ
pathology. Patients’ examination was carried out according to scheme, including clinical methods, morphometric methods,
biometric study, x-ray methods, dental computed tomography and serum C-RP concentration which was determined by
enzyme-linked immunoassay. Results: systemic metabolism of connective tissue at patients with dysplasia is characterized
by release of glycoproteins, a decrease in sulfated glycosaminoglycan. Beyond, they also is determined rheological properties
of blood, which serves as an explanation for occurrence of typical disorders of hemostasis in DAA, affecting thrombophilia
caused by systemic inflammatory response, which explained predominance of degradation of glycosaminoglycan on their
synthesis. Conclusions: as a result of the obtained data, it was revealed that at children with temporomandibular joint
disease were a significant increase in glycosoaminglican level in serum when compared with a group of healthy children.