MORPHOLOGICAL FEATURES OF MESENTERIAL LYMPH NODES IN EXPERIMENTAL HYPOTHYROIDIS IN THE MOTHER

Authors

  • Feruza Kh. Azizova Tashkent Medical Academy
  • Mokhizoda A. Mirtolipova Tashkent Medical Academy

Keywords:

hypothyroidism in pregnant women, offspring, postnatal ontogenesis, mesenteric lymph nodes.

Abstract

According to statistics, half of the world's population has health problems related to the thyroid gland.

The effect of experimental hypothyroidism in female rats on the development, formation and growth of mesenteric lymph nodes (MLN) of the offspring was  studied.

Hypothyroidism in female rats was  induced by oral administration of the antithyroid drug Mercazolil at a dose of 0.5 mg per 100 g of body weight for 21 days. After establishing a stable decrease in the concentration of free thyroxine in the blood serum, the females were  fertilized by healthy males. During pregnancy and lactation, females continued to be administered a maintenance dose of the drug.

At 3, 7, 14, 21 and 30 days after birth, the development and formation of MLN offspring obtained from females with experimental hypothyroidism were morphologically studied.

It has been established that in offspring born under conditions of maternal hypothyroidism, the time parameters for the formation of structural and functional zones of MLN, especially its T-dependent zones, significantly lag behind the control.

Author Biographies

Feruza Kh. Azizova , Tashkent Medical Academy

Professor of the department of Histology and Medical Biology,
Tashkent Medical Academy, Tashkent, Uzbekistan

Mokhizoda A. Mirtolipova , Tashkent Medical Academy

Assistant of the department of Histology and Medical Biology,
Tashkent Medical Academy, Tashkent, Uzbekistan

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Published

2023-10-04

How to Cite

Feruza Kh. Azizova, & Mokhizoda A. Mirtolipova. (2023). MORPHOLOGICAL FEATURES OF MESENTERIAL LYMPH NODES IN EXPERIMENTAL HYPOTHYROIDIS IN THE MOTHER. Central Asian Journal of Medicine, (3), 250-257. Retrieved from https://mail.journals.tma.uz/index.php/cajm/article/view/711

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