THYROID STATUS OF THE OFFSPRINGS OBTAINED FROM FEMALES WITH EXPERIMENTAL HYPOTHYROSIS IN THE DYNAMICS OF POSTNATAL ONTOGENESIS

Abstract

Thyroid dysfunction remains one of the most pressing problems in the world. Among them, a special place is occupied by hypothyroidism in pregnant women, which, according to various sources, is observed in 2-2.5% of all pregnant women and can manifest itself in subclinical or manifest forms. Hypothyroidism in pregnant women has a harmful effect on the offspring, leading to structural and functional disorganization of the own thyroid system, discoordination of immunogenesis processes, disruption of cell proliferation and differentiation, growth and formation of organs and tissues. The relevance of the problem of hypothyroidism in pregnant women in the practice of doctors of various specialties is undeniable, since due to the lack of thyroid hormones necessary for the normal development and functioning of almost every cell of the human body, serious changes occur in all organs and systems. Therefore, studying the effect of hypothyroidism in pregnant women on the structural and functional characteristics of the offspring’s immune system in early postnatal ontogenesis is one of the most important current tasks of medicine.