THE ROLE OF GROWTH FACTORS IN THE FUNCTIONING OF THE PLACENTAL SYSTEM
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Keywords

pregnancy
placental dysfunction
cytokines

How to Cite

Eshimbetova , G., Musakhodzhayeva , D., Shaikhramova, . N., Jurayeva, . D., & Kholmatova, . S. (2025). THE ROLE OF GROWTH FACTORS IN THE FUNCTIONING OF THE PLACENTAL SYSTEM. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, 1(5). Retrieved from https://mail.journals.tma.uz/index.php/jesm/article/view/1321

Abstract

Objective: to study serum growth factors in women with placental dysfunction (PD).

Material and methods. The study involved 47 pregnant women, with a gestation period of 26-40 weeks, with an established diagnosis of placental dysfunction, who were under observation in the obstetric department of the City Maternity Complex No. 3 in Tashkent. Determination of serum levels of growth factors was carried out by ELISA, in accordance with the manufacturer's recommendations.

Results. It was found that pregnant women with PD at 26-40 weeks of gestation have significant dysregulation of growth factors and vascular activity, which is manifested in a significant decrease in the levels of VEGF-A and PlGF in the peripheral blood serum, as well as a significant increase in the level of sFlt-1. These changes lead to a pronounced imbalance in the ratio of sFlt-1 to PlGF, which can contribute to deterioration of placental function and is associated with the development of pathological conditions.

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