THE ROLE OF MOLECULAR GENETIC MARKERS IN THE CLINICAL COURSE OF CERVICAL INTRAEPITHELIAL NEOPLASIA
No. 2 (2022), Articles
No. 2 (2022)

THE ROLE OF MOLECULAR GENETIC MARKERS IN THE CLINICAL COURSE OF CERVICAL INTRAEPITHELIAL NEOPLASIA

Articles
Published 2022-05-25
Dilbar Nazhmutdinova
Tashkent Medical Academy
Iroda Kamilova
Tashkent Medical Academy
Umida Shukurova
Tashkent Medical Academy
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Keywords

Cervical intraepithelial neoplasia
Genes of oncosuppressor proteins – TP53
Genes of enzymes of estrogen metabolism – CYP1A2
SULT1A1
Genes of matrix metalloproteinases – MMP-1
Urogenital infection

How to Cite

Nazhmutdinova , D., Kamilova , I., & Shukurova , U. . (2022). THE ROLE OF MOLECULAR GENETIC MARKERS IN THE CLINICAL COURSE OF CERVICAL INTRAEPITHELIAL NEOPLASIA. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, (2), 17-19. Retrieved from https://mail.journals.tma.uz/index.php/jesm/article/view/262
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Abstract

When studying the clinical course of cervical intraepithelial neoplasia in 226 women with molecular genetic analysis, it was revealed that the correlation of alleles and genotypes of genes of oncosuppressor proteins, enzymes of estrogen metabolism and matrix metalloproteinases, confirmed by indicators of relative risk, were the basis for establishing the severity of the clinical course and the risk of developing this multifactorial pathology, by studying anamnestic, somatic data, complaints and the presence of urogenital infections in women with neoplasia of the cervical epithelium.

 

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