REVIEW OF METHODS FOR MODELING ISCHEMIC STROKE IN VIVO
No. 1 (2022), Articles
No. 1 (2022)

REVIEW OF METHODS FOR MODELING ISCHEMIC STROKE IN VIVO

Articles
Published 2023-01-09
B.U. Irisqulov
Department of Physiology and Pathophysiology, Tashkent Medical Academy, Tashkent
I.F. Abdullaev
Laboratory of Experimental Biophysics, Center for Advanced Technologies, Tashkent & Laboratory of Membrane Biophysics, Institute of Biophysics and Biochemistry, Tashkent
A.R. Makhmudov
Laboratory of Experimental Biophysics, Center for Advanced Technologies, Tashkent & Department of Chemistry of Natural Compounds, Faculty of Chemistry, National University of Uzbekistan, Tashkent
A.Yu. Baev
Laboratory of Experimental Biophysics, Center for Advanced Technologies, Tashkent
A.U. Sariev
Department of Physiology and Pathophysiology, Tashkent Medical Academy, Tashkent & Laboratory of Experimental Biophysics, Center for Advanced Technologies, Tashkent
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Keywords

stroke
animal model
ischemia
pathophysiology
MCAO

How to Cite

Irisqulov, B., Abdullaev, I., Makhmudov, A., Baev, A., & Sariev, A. (2023). REVIEW OF METHODS FOR MODELING ISCHEMIC STROKE IN VIVO. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, (1), 24-31. Retrieved from https://mail.journals.tma.uz/index.php/jesm/article/view/286
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Abstract

Ischemic stroke is a leading cause of permanent disability worldwide. It is accompanied by devastating long-lasting motor, sensory and cognitive deficits. Currently, there is no effective treatment for ischemic stroke except intravenous perfusion with tPA, which has a limited therapeutic window and success rate.  Therefore, scientists have been developing animal models to investigate the pathophysiology behind ischemic damage and discover new therapeutic drugs and rehabilitation protocols to alleviate stroke-induced deficits in patients. Developing tests that can identify and quantify behavioral and histo-pathophysiological impairments after stroke is essential to expand the development of translational therapies. In this review, we will discuss current in vivo stroke models and examination methods to assess functional outcomes after induction of experimental stroke in laboratory animals.

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