MORPHOLOGICAL CHARACTERISTICS OF THE LUNG TISSUE IN THE REPRODUCTION OF A NEW EXPERIMENTAL MODEL OF ACUTE LUNG ABSCESS AGAINST THE BACKGROUND OF DIABETIC MICROANGIOPATHY

Abstract

A morphological study of lung tissue in animals with an experimental model of acute purulent-destructive lung disease on the background of diabetic angiopathy was carried out. It has been established that in the initial phase of modeling purulent inflammation against the background of diabetes mellitus, diffuse plethora of blood vessels, disorganization of their walls, development of edema and perivascular hemorrhage, leukocyte infiltration of the interalveolar septa and the appearance of foci of confluent inflammation and distelectasis of the lung tissue are noted. On the 7th day after modeling the pathological process, there is an increase in dyscirculatory, destructive and inflammatory processes in the form of paralytic expansion of the vascular wall due to fibrinoid swelling, increased migration of leukocytes into the lung tissue, the development of destruction, the formation of microabscesses, compaction of the lung tissue due to interstitial inflammation and distelectasis