FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS
Vol. 1 No. 3 (2022), Articles
Vol. 1 No. 3 (2022)

FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS

Articles
Published 2022-06-17
U.S. Khasanov
Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan
U.N. Vokhidov
Department Otorinolaryngology, Tashkent State Dental Institute, Republic of Uzbekistan
J.A. Djuraev
Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan
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Keywords

paranasal sinuses, polyp, allele, genotyping

How to Cite

Khasanov, U., Vokhidov, U., & Djuraev, J. (2022). FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, 1(3), 54-58. Retrieved from https://mail.journals.tma.uz/index.php/jesm/article/view/329
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Abstract

Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C/C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. In addition, these data emphasize the prognostic significance of the C/C genotype of the rs1800896 polymorphism of the IL-12B gene in the development of CPMS. In carriers of this genotype, the relative risk of developing CPMS increases by more than 3 times, compared with carriers of other genotypic variants of the rs3212227 polymorphism of the IL12B gene..

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