REVIEW OF EARLY CLINICAL MANIFESTATIONS OF MULTIPLE SCLEROSIS

Abstract

Multiple sclerosis (MS) is a chronic demyelinating disorder that affects the central nervous system. Until recently, little attention was paid to the early preclinical and clinical manifestations of multiple sclerosis. It is only in the past decade that researchers have started to focus on the prodromal phase of the disease. Knowledge of the prodrome is important for suspecting and, eventually, diagnosing the disease. This article synthesizes the current literature regarding the early clinical manifestations observed in patients with MS. Because the early identification of individuals diagnosed with MS is of considerable significance, as it facilitates the prompt implementation of therapeutic strategies designed to mitigate the risk of relapses and long-term disability.