Abstract
Background. Over the past fifty years, there has been a steady increase in the prevalence of diabetes mellitus all over the world. This trend remains very characteristic of industrialized countries, where, along with coronary heart disease, obesity and metabolic syndrome, diabetes mellitus is registered from 5% to 10%. The problem of treating purulent diseases of soft tissues, remaining relevant throughout the history of mankind, under conditions of a high incidence of diabetes mellitus, is becoming more and more important both clinically and socially.
Material and methods. The object of the study was the data of a comprehensive examination and treatment of 123 patients with wound infection complicated by sepsis against the background of diabetes mellitus from 2011 to 2022. The subject of the study was: general and local clinical status of patients, laboratory blood parameters, including cytokine profile, predictors of inflammatory response, morphometric impressions of the wound, biopsionic material of the wound, wound exudate. In the dissertation, clinical, immunological, hematological, biochemical, morphological, microbiological, planimetric and statistical research methods were used.
Result. It has been proved that the use of the method developed by us for diagnosing the phase of the wound process complicated by sepsis in patients with diabetes mellitus makes it possible to increase the probability of diagnosing the development of generalization of the inflammatory process and to determine the option of using the method of treating wound infection.
Conclusion. The introduction of a new therapeutic and diagnostic algorithm for the local treatment of wound infection complicated by sepsis in patients with diabetes mellitus, developed by us, made it possible to increase the number of good and satisfactory treatment results, reduce the number of cases with unsatisfactory treatment results and avoid cases with fatal outcomes in the main group of patients.