METABOLIC SURGERY FOR COMPLEX PHENOTYPES OF METABOLIC SYNDROME
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Keywords

Metabolic syndrome
bariatric surgery
phenotyping
insulin resistance
GERD
NAFLD
GLP-1

How to Cite

Khamdamov , I. . (2025). METABOLIC SURGERY FOR COMPLEX PHENOTYPES OF METABOLIC SYNDROME: from obesity index to hormonal and gastrointestinal profiles. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, 1(3), 89-93. Retrieved from https://mail.journals.tma.uz/index.php/jesm/article/view/1306

Abstract

Background: Metabolic syndrome (MetS) is a heterogeneous condition influenced by diverse endocrine, anatomical, and inflammatory profiles. As bariatric surgery evolves into metabolic surgery, understanding patient-specific phenotypes becomes essential for personalized treatment.

Objective: To review and analyze current evidence on how metabolic surgery outcomes are affected by individual variations in insulin resistance, GERD, NAFLD, gut hormone response, and anatomical gastric parameters.

Methods: A narrative literature review was conducted using PubMed, Scopus, and Embase, including clinical trials and cohort studies from 2005 to 2024. Key search terms included «metabolic syndrome», «bariatric surgery», «phenotypes», «GERD», «NAFLD», and «gut hormones».

Results: Evidence shows that patients with high HOMA-IR and low C-peptide respond better to malabsorptive procedures like OAGB or RYGB, while those with mild insulin resistance and active GLP-1 signaling benefit from restrictive options such as LSG. The presence of GERD and anatomical variation in stomach axis influences surgical choice, with anti-reflux modifications proving superior in high-risk patients. NAFLD, increasingly viewed as a «hepatocentric» component of MetS, may also require tailored surgical strategies. Gut hormone dynamics and microbiota profiles are emerging as key modifiers of metabolic outcomes.

Conclusion: Metabolic surgery should no longer be viewed as a singular approach. Recognizing and stratifying phenotypic complexity in MetS patients allows for more rational procedure selection and improved long-term outcomes. A shift toward algorithm-driven, phenotype-adapted surgery is both necessary and imminent.

Keywords: Metabolic syndrome, bariatric surgery, phenotyping, insulin resistance, GERD, NAFLD, GLP-1.

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References

Grundy SM. Metabolic syndrome update. Trends Cardiovasc Med. 2016;26(4):364–373.

Alberti KG, Zimmet P, Shaw J. The metabolic syndrome — a new worldwide definition. Lancet. 2005;366(9491):1059–1062.

Rubino F, Nathan DM, Eckel RH, et al. Metabolic surgery in the treatment algorithm for type 2 diabetes. Diabetes Care. 2016;39(6):861–877.

Cummings DE, Rubino F. Metabolic surgery for the treatment of type 2 diabetes in obese individuals. Diabetologia. 2018;61(2):257–264.

Himpens J, Dobbeleir J, Peeters G. Long-term outcomes of laparoscopic sleeve gastrectomy. Obes Surg. 2010;20(2):159–165.

Parmar CD, Mahawar KK. Management of GERD in bariatric patients: the case for tailored surgery. Clin Obes. 2018;8(6):388–394.

Mahawar KK, Parmar C, Graham Y, et al. Limb lengths in gastric bypass: do they matter? Surg Obes Relat Dis. 2016;12(2):379–384.

Kwon Y, Kim HJ, Hur KY, et al. Tailored limb length in OAGB: impact on weight loss and metabolic parameters. Surg Obes Relat Dis. 2019;15(4):608–614.

Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50(8):1844–1850.

Tremaroli V, Karlsson F, Werling M, et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome. Cell Metab. 2015;22(2):228–238.