DEVELOPMENT OF METHODS FOR PREDICTING PERITONITIS IN PATIENTS WITH ACUTE ADHESIVE INTESTINAL OBSTRUCTION

// Collection of abstracts of the scientific and practical conference «Current Problems of Surgical Soft Tissue Infections» (2024), Tashkent, October 28

Abstract

In acute intestinal obstruction complicated by peritonitis, lipid peroxidation and phospholipase activity were increased to a greater extent than in the uncomplicated form of ileus. The level of diene conjugates in the second group increased relative to the norm during the entire follow-up period by 57.4, 110.4, 89.6 and 60.2% (p<0.05), respectively. 28.5, 30.8 and 26.4% (p < 0.05), respectively. Analysis of studies of lipid metabolism in patients with acute intestinal obstruction shows that, regardless of the form of ileus, a significant intensification of membrane lipid peroxidation and activation of phospholipase A2 occurs at the earliest stages of follow-up before surgery. Moreover, in patients whose acute intestinal obstruction was complicated by peritonitis, these pathological processes were more pronounced. This significantly aggravated the course of the early postoperative period, including an increase in the severity of the endogenous intoxication syndrome.