CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF ACUTE PURULENT-DESTRUCTIVE LUNG DISEASES

Abstract

Patients with acute abscesses and lung gangrene exhibit certain associated changes in the large bronchi of catarrhal and sclerotic bronchitis, characterised by a predominance of dystrophic changes, exposure of basal cells, enlargement of intercellular spaces, and instability of the bronchial epithelium. This instability is manifested by the proliferation of goblet cells and a nested change in the functional activity of the epithelial layer cells. There is a possibility of forming three morphological variants of the restructuring of the respiratory system in patients with purulent-destructive lung diseases, depending on the peculiarities of the processes of fibrinogenesis and fibrin stabilisation, the activity of phagocytic cells and the nature of the restructuring of the microcirculatory bed. Structural-spatial reorganisation of the alveolar epithelium's basement membranes and the blood vessels' endothelium in patients with acute abscesses and lung gangrene proceeds through splitting and destruction. The nature of restructuring the microcirculatory bed of the respiratory system in patients with acute abscesses and lung gangrene is stereotypical, and the severity of morphological changes depends on the clinical variant of the course of purulent-destructive lung diseases.